LING LABORATORY 
Cycle and Genome Instability

CN
​周雷

学习经历

(1) 1994-10 至 2000-05, 威斯康星大学麦迪逊分校, 生理/神经生理, 博士 

(2) 1992-09 至 1994-10, 中国医学科学院协和医科大学肿瘤研究所, 核医学, 硕士 

(3) 1988-09 至 1992-07, 南开大学, 生物物理, 学士


工作经历

(1) 2020-11 至 今, 广东省深圳湾实验室, 分子生理学研究所, 研究员 

(2) 2015-07 至 2020-10, 弗吉尼亚联邦大学, 医学院生理系, 其他副高级职称

(3) 2008-09 至 2015-07, 弗吉尼亚联邦大学, 医学院生理系, 其他中级职称 

(4) 2005-09 至 2008-09, 哥伦比亚大学, 医学院神经生物学中心, 其他初级职称


出版物

(1) Liu, Qinglian; Liang, Ce; Zhou, Lei Z ; Structural and functional analysis of the Hsp70/Hsp 40 chaperone system., Protein Science, 2020, 29

(2): 378-390 () (2) Yang Jiao; Zong Yinong; Su Jiayue; Li Hongtao; Zhu Huanyu; Columbus Linda; Zhou Lei Z ; Liu Qinglian ; Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s, Nature Communications, 2017, 8(1): 0-1201 (

(3) Chang Liu; Changan Xie; Khade Grant; Zhuocheng Su; Weihua Gao; Qinglian Liu; Lei Zhou L ; P atch-clamp fluorometry–based channel counting to determine HCN channel conductance, Journal of G eneral Physiology, 2016, 148(1): 65-76 (

(4) Lei Zhou L ; Qinglian Liu ; Aligning Experimental and Theoretical Anisotropic B-Factors: Wat er Models, Normal-Mode Analysis Methods, and Metrics, The Journal of Physical Chemistry B, 2014, 118(15): 4069-4079 (

(5) Gao Weihua; Su Zhuocheng; Liu Qinglian; Zhou Lei Z ; State-dependent and site-directed phot odynamic transformation of HCN2 channel by singlet oxygen, Journal of General Physiology, 2014, 1 43(5): 633-644 (

(6) Lei Zhou L ; Diomedes E.Logothetis ; The where and how of PIP regulation of cone photorecept or CNG channels, The Journal of General Physiology, 2013, 141(4): 403-407 (

(7) Qi Ruifeng; Sarbeng Evans Boateng; Liu Qun; Le Katherine Quynh; Xu Xinping; Xu Hongya; Ya ng Jiao; Wong Jennifer Li; Vorvis Christina; Hendrickson Wayne A; Zhou Lei Z ; Liu Qinglian ; Allost eric opening of the polypeptide-binding site when an Hsp70 binds ATP, NATURE STRUCTURAL %26 MOLEC ULAR BIOLOGY, 2013, 20(7): 900-907 (

(8) Shengjun Wu; Zhanna V.Vysotskaya; Xinping Xu; Changan Xie; Qinglian Liu; Lei Zhou L ; State -Dependent cAMP Binding to Functioning HCN Channels Studied by Patch-Clamp Fluorometry, Biophysic al Journal, 2011, 100(5): 1226-1232 (

(9) Xinping Xu; Farzana Marni; Shengjun Wu; Zhuocheng Su; Faik Musayev; Sabisha Shrestha; Cha ngan Xie; Weihua Gao; Qinglian Liu; Lei Zhou L ; Local and Global Interpretations of a Disease-Caus ing Mutation near the Ligand Entry Path in Hyperpolarization-Activated cAMP-Gated Channel, Struct ure, 2012, 20(12): 2116-2123 (

(10) Farzana Marni; Shengjun Wu; Gaurav M.Shah; Xin-ping Xu; Amber R.Hackett; Changan Xie; Sa bisha Shrestha; Lin Liu; Qinglian Liu; Lei Zhou L ; Normal-Mode-Analysis-Guided Investigation of Cr ucial Intersubunit Contacts in the cAMP-Dependent Gating in HCN Channels, Biophysical Journal, 20 12, 103(1): 19-28 ()